ORIC’s senior management team has decades of experience in the biotech and pharmaceutical industries, having worked in drug discovery and development at companies such as Merck, Pfizer and Genentech.
Jacob Chacko, MD
Chief Executive Officer
Dr. Chacko was most recently CFO of Ignyta, a NASDAQ-listed precision oncology company acquired by Roche in February 2018. At Ignyta, he had a broad operational role and helped raise over $500 million in capital. During his tenure, the company grew from fewer than 20 employees and a $50 million enterprise value to 125 employees and a $1.7 billion enterprise value at the time of acquisition. Prior to Ignyta, Dr. Chacko was an investor at TPG Capital, where he helped lead teams that completed acquisitions having an aggregate value of over $10 billion. He has served on the board of directors of RentPath and EnvisionRx and was a board observer to Par Pharmaceutical, IMS Health and Quintiles Transnational. He previously served on the board of the Packard Children’s Health Alliance at the Lucile Packard Children’s Hospital Stanford.
Dr. Chacko concurrently received his M.D. with AOA honors from UCLA and his M.B.A. with Distinction from Harvard Business School. Prior to that, he was a consultant serving healthcare clients at McKinsey & Company. He received a M.Sc. from Oxford University as a Marshall Scholar and undergraduate degrees from the University of Southern California, where he graduated as the University Valedictorian. He currently serves on the board of directors of Bonti and AROG Pharmaceuticals and chairs the Western Regional Selection Committee for the Marshall Scholarship.
Valeria Fantin, Ph.D.
Chief Scientific Officer
Dr. Fantin is a biopharmaceutical leader with over a decade of experience in exploratory biology and oncology drug discovery and development. Prior to joining ORIC, she was Vice President of Tumor Cell Biology at Pfizer, responsible for advancing small molecules from target validation to Phase 2 proof-of-concept. Dr. Fantin was also responsible for identifying business development opportunities and leading strategic alliances to broaden Pfizer’s efforts in oncology research.
Prior to joining Pfizer, Dr. Fantin held leadership positions at Agios Pharmaceuticals where she created and advanced an exploratory program of novel cancer metabolism targets into drug discovery, and led the execution of the company’s flagship isocitrate dehydrogenase program. Her earlier career as a researcher included positions focused on epigenetics and kinase drug discovery projects with Merck Research Laboratories and ARIAD Pharmaceuticals. She has contributed to the discovery of numerous compounds currently under clinical evaluation and the development of Zolinza® (vorinostat) and Ibrance® (palbociclib).
Dr. Fantin was awarded the Rising Star Award by the Healthcare Businesswomen’s Association. Dr. Fantin completed postdoctoral training in cancer metabolism and signal transduction at Harvard Medical School and the Howard Hughes Medical Institute, and earned her Ph.D. in molecular and cellular biology from Dartmouth Medical School.
Leonard Reyno, M.D.
Chief Medical Officer
Prior to joining ORIC, Leonard Reyno served as Senior Vice President and Chief Medical Officer at Agensys, a subsidiary of Astellas Pharma, where he led clinical stage development through clinical proof of concept. Dr. Reyno’s prior positions in industry included Global Medical Director for Taxotere/Breast cancer at Aventis, Medical Director and Lead Clinical Scientist for Herceptin at Genentech and Senior Director of Oncology at Cytokinetics.
Before joining industry, Dr. Reyno was an academic oncologist, where he had both extensive experience as a clinician (especially in breast and genitor-urinary malignancy) as well as serving as Principal Investigator on multiple trials with the National Cancer Institute of Canada. Dr. Reyno was Head of Medical Oncology and the Oncology Clinical Research Unit at Dalhousie University from 1999- 2003, and previously Associate Professor of Medicine at McMaster University from 1993-1999.
Dr. Reyno received his M.D. from McMaster University in 1986. He completed fellowships in internal medicine and medical oncology at McMaster and further training in drug development at the University of Maryland at Baltimore as the McEachern Fellow of the National Cancer Institute of Canada from 1991-1993. He has authored more than 25 scientific publications in major journals.
Vice President, Human Resources
Brian Muma has a broad background in human resources with deep understanding of the biopharmaceutical industry acquired from HR leadership positions across the spectrum from discovery to commercialization. Mr. Muma was previously Vice President of Human Resources for Roche China. Prior to the assignment in China, Brian held senior HR leadership roles at Genentech in R&D, Manufacturing, Commercial Operations and Total Rewards Strategy. Earlier in his career, he was an executive compensation consultant at KPMG and Mercer.
Mr. Muma has completed certification courses in change management, advanced project management and 360 degree feedback as well as advanced training in executive coaching and emotional intelligence. He holds a Bachelors degree in Economics and an MBA from the University of Michigan.
General Counsel, Corporate Secretary, and Senior Director of Business Development
Krys Corbett has more than 20 years of experience in licensing transactions, business development and alliance management, including more than 15 in biopharma.
In previous roles at Genentech and Roche, Ms. Corbett focused on strategic alliances and transactions in Roche Partnering, Genentech Alliance Management and Portfolio Planning, and Genentech Transactional Law. She led transactions for licensing, launch or label expansions of Venclexta®, Lucentis®, Rituxan Hycela®, Erivedge®, and development-stage assets, and provided legal and partnering support for products including Avastin®, Xolair®, Rituxan®, and Cotellic®.
Prior to Genentech/Roche, she was at Wilson Sonsini Goodrich and Rosati, where she advised clients on licensing and M&A transactions. She received her J.D. with honors from Duke University School of Law.
Director of Finance & Operations
Sara Coblin previously worked as Director of Finance at Genentech supporting global CMC operations. Prior to that role, she held other finance positions in R&D, FP&A and Alliance Management supporting partnerships on Ocrevus®, Rituxan®, Tarceva® and many other pipeline programs. Earlier in her career, she worked at Sun Microsystems and Arthur Andersen specializing in business process improvement and ERP systems implementation.
She holds a BA in Economics and Computer Applications from the University of Notre Dame. She also earned an MBA from University of California, Berkeley.