Our bold vision is to develop and commercialize innovative therapies that address cancer resistance, including by making existing therapies work better and longer.

Profound advancements in oncology drug development have expanded the treatment options available to patients, yet therapeutic resistance and relapse continue to limit the efficacy and duration of clinical benefit of such treatments. Cancer resistance continues to be one of the most daunting challenges facing patients, clinicians and researchers in oncology today. At ORIC, our resistance platform is focused on three areas:

1

Innate
resistance

Derives from an unaddressed oncogenic driver that promotes tumor growth
2

Acquired
resistance

The result of an induced or enriched oncogenic driver that arises in response to treatment
3

Bypass
resistance

The activation of a compensatory signaling pathway in response to treatment
Large cancer cell in circle with multiple cancer cells in background

Clinical trials now enrolling

We are currently enrolling a Phase 1b study of rinzimetostat (ORIC-944) in prostate cancer in combination with AR inhibitors.

We are also enrolling a Phase 1b study of enozertinib (ORIC-114) in NSCLC patients with EGFR exon 20 mutations as a single-agent, in combination with amivantamab and hyaluronidase-lpuj subcutaneous injection (SC amivantamab), and in combination with chemotherapy, as well as in NSCLC patients with EGFR PACC mutations as a single-agent. Do you qualify?

African american woman expressively talking with colleagues

Motivated by a shared purpose

Our collaborative, open culture gives each of us the authority, responsibility and support to do cutting-edge work on therapies for treatment-resistant cancers.